The concept of macro-ecumenism is quite new in Latin America. It emerges from the quest of a new identity and role of indigenous and Afro-American social groups and cultures. The discussion is made mainly from the view point of the Catholic Church, but it includes the view points of all the other Christian groups involved in this new kind of inter-religious dialogue, which is not a product of the so called ecumenism. The indigenous and Afro-American cultures and religions play a special role in this new approach to the differences and similarities among the religions. On the background of the discussion there are some issues already treated in the Theology of Liberation, like "Inculturation", "Black Theology", "Indigenous Theology", "Religious Dialogue" etc. But those concepts are seen from quite new perspectives, bringing a fresh wind to the dramatic relations between the religions present in the historical process of the three Americas. There are many potentially polemic issues on the table, but the macro-ecumenism seems to be an important chapter in the future relations between the religions in Latin America.